By Gayatri Rao Dutt & Pradeep Sathe
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Extra resources for Aditya, The Man from Nowhere 1: The Inner Curse
Finally, improvements in microRNA detection technology and computational methods will certainly lead to the discovery of important new microRNA genes and microRNA–target interactions, particularly for rare cell types and stem cell niches. Progress in microRNA research has been astonishingly rapid over the past six years or so, and we can be sure that the future will see an acceleration of this pace of discovery, yielding a wealth of exciting new biological insights and human health applications.
Clearly, high-throughput approaches and bioinformatics will have a primary role in the future of clinical oncology and pathology. In addition, microRNAs will be used in targeted cardiovascular therapy and they will be a central tenet in ‘translational medicine’. To fully realize the potential of microRNAs as biomarkers to aid in drug development, industry must implement best practices for biomarker development, and promote translational research strategies. The biggest obstacles to turning discovery from bench to bedside are not only, in the advancement of technology, but also the necessary regulatory approvals.
This model is a generic model of the biogenesis of microRNAs in animals. The lin-4 miRNA and the lin-14 mRNA are shown as examples. The corresponding factors that have been implicated in the biogenesis of microRNAs in C. elegans are Drsh-1 (Drosha), Pash-1 (Pasha), Dcr-1 (Dicer) and Alg-1/2 (Ago). (a) 10 Discovery of microRNAs in various organisms MicroRNA gene identification and expression analysis The first microRNAs were identified through forward genetic screens in C. elegans, as is described below.
Aditya, The Man from Nowhere 1: The Inner Curse by Gayatri Rao Dutt & Pradeep Sathe